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Crazy 8 Initiative Award Program

Grants to USA, Canada, and International MDs
and PhDs for Pediatric Cancer Research

Agency Type:

Foundation / Corporation

Funding Source:

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Alex’s Lemonade Stand Foundation (ALSF)

LOI Date:


Deadline Date:

08/05/21 8:00 PM ET


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Grants to USA, Canada, and International MDs and PhDs affiliated with academic institutions for pediatric cancer research. Applicants must submit an LOI prior to submitting a full proposal. Funding is intended for proposals that are designed to address very challenging issues in pediatric cancer research with the ultimate goal of curing pediatric malignancies.

The Crazy 8 Initiative Award will fund research into innovative and rigorous approaches that directly address the most intractable issues in pediatric cancer research today. This award is designed to coalesce cross-disciplinary cores of scientists working collaboratively in order to accelerate the pace of new cure discovery. 

Crazy 8 Disciplines:

  1. Embryonal brain cancers
  2. High-grade gliomas
  3. Fusion-positive sarcomas
  4. Fusion-negative sarcomas
  5. Leukemias
  6. Neuroblastoma
  7. Big data
  8. Catalyzing clinical trials

Crazy 8 Research Themes:

  1. Developmental Origins of Pediatric Cancers
  2. Drugging Currently Undruggable Pediatric Cancer Drivers
  3. Developing Novel Immunotherapies
  4. Discovery and Development of Novel Pediatric Cancer Drug Targets

The proposal should address a topic that is responsive to at least one of the four pediatric cancer research themes listed above. It is expected that successful applications will address one or more of the eight disciplines that formed the basis of the Crazy 8 Initiative. For 2021, priority will be given to projects involving innovative studies of high-grade gliomas, nonmedulloblastoma embryonal brain tumors, non-Ewing Sarcoma fusion-positive sarcomas, fusion-negative sarcomas, big data, and/or catalyzing clinical trials. . Investigators with proposals focusing on leukemias, neuroblastoma, Ewing sarcoma, and medulloblastoma are welcome to apply, but ALSF has set areas of prioritization for this round of funding in order to fund a broadly representative community of investigators working across many different cancer types. 

GrantWatch ID#:

GrantWatch ID#: 186473

Estimated Total Program Funding:


Number of Grants:

ALSF anticipates funding one to two awards in this round of funding.

Estimated Size of Grant:

Depending on the type of project and the size of the team, the requested budget should be in the range of $3-5 million USD over four years.

Term of Contract:

Four years

Additional Eligibility Criteria:

• Applicants must have an MD, PhD, or MD/PhD or equivalent and be appointed as faculty (or equivalent) at an academic institution.
• Applicants must have a track record of publication and funding productivity that demonstrates that the project can be accomplished by the investigators.
• Applicant institutions may be based in the United States or abroad, and applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.

• Proposals with a sole/primary focus on patients >21 years of age will not be considered.
• Funds may not be used for research utilizing human embryonic stem cells or non-human primates. Research with human induced pluripotent stem cells is permissible.

Pre-Application Information:

- Letter of Intent Due: April 26, 2021 by 8:00 PM ET
- Invitation to Submit Full Proposal: By June 11, 2021
- Full Application Due: August 5, 2021
- Invitation to Present: By November 5, 2021
- Finalist Virtual Presentations: December 8-10, 2021
- Grant Start Date: Q1 2022

The award selection process involves three stages: (1) a letter of intent to narrow the pool to the projects most in line with the scope of the Crazy 8 Initiative; (2) a full proposal to select award finalists; and (3) a virtual presentation to ALSF leadership and the Crazy 8 Scientific Advisory Board to choose the award recipient(s).

Investigators may submit more than one LOI.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit an LOI Online:

For questions regarding this grant mechanism, reach out to Anna Greene, Director of Science, by email at

After your application has been successfully submitted, an email confirmation will be sent. If you do not receive a confirmation email, please contact

Alex’s Lemonade Stand Foundation for Childhood Cancer
111 Presidential Blvd., Suite 203
Bala Cynwyd, PA 19004 USA
Phone: 866.333.1213

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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