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Clinical Pilot and Feasibility Award

Grants to USA, Canada, and International
Researchers for Cystic Fibrosis Projects

Agency Type:

Foundation / Corporation

Funding Source:

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Cystic Fibrosis Foundation (CFF)

LOI Date:


Deadline Date:

08/18/21 5:00 PM (EST)


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Grants to USA, Canada, and International researchers for cystic fibrosis research projects. Applicants are required to submit a letter of intent prior to submitting a full application. Priority is given to projects that support innovative approaches, explore under-researched topics, or investigate more creative avenues of research to address the problems of cystic fibrosis.

The Clinical Pilot and Feasibility Award is intended to support a project involving human subjects or samples that will develop and test new hypotheses and/or new methods in research areas relevant to cystic fibrosis.

The intent of the Clinical Pilot and Feasibility Award is to enable investigators to collect sufficient preliminary data to determine the best strategies and methods for approaching a major question that ultimately will require assessment through a larger scale research and/or multi-center, collaborative clinical trial.

The CF Foundation seeks applications for the Clinical Pilot and Feasibility Award from all areas of clinical research that will have an impact on the lives of people with CF. However, the following research areas are of particular interest to the CF Foundation as they will address critical needs of people with CF:

  • Studies that investigate CF disease complications (lung, GI tract, liver, pancreas, reproduction, mental health, endocrine etc.)
  • Strategies to improve care and quality of life of people with CF
  • Assessment and validation of biomarkers, clinical trial tools, outcome measures and efficacy endpoints
  • Translational or clinical studies in lung transplant1 research
  • Characterization of CF disease manifestations and management in the era of highly effective modulator therapy
  • Novel interventions that improve CF patient care and outcomes
  • Studies designed to translate laboratory findings of disease pathogenesis/treatment to clinical evaluation
  • Studies that identify and characterize racial, ethnic, and/or societal contributors to CF disease expression and management

Areas of Encouragement

In addition to CF Foundation Areas of Interest, extensive survey input from the CF community (people with CF, family members, and caregivers) have identified key research Areas of Encouragement that are most important to them. The areas selected by the CF community are listed below in order of prioritization. Applications may address any topic area advancing CF care, treatment, or research. However, applications addressing the following areas in CF are particularly encouraged:

  1. Respiratory microorganism detection and treatment
  2. Gastrointestinal symptoms (including, but not limited to, gastroesophageal reflux disease (GERD), Distal Intestinal Obstruction Syndrome  (DIOS), and pancreatitis)
  3. Reducing treatment burden
  4. CF-related diabetes
  5. Diet and nutrition
  6. Mental health
  7. CF-related liver disease
  8. Exercise
  9. Sinus disease
  10. Allergies and asthma in CF
  11. Alternative/holistic treatments and therapies
  12. Sexual reproductive health
  13. Bone/joint health
  14. Pain management

Direct costs may be requested for:

  • Salary and Benefits
  • Research supplies
  • Equipment
  • Research-related subject costs
  • Consultant costs
  • Support for multidisciplinary collaborations, including travel
  • Travel costs for scientific/technical meeting(s)

GrantWatch ID#:

GrantWatch ID#: 194625

Estimated Size of Grant:

Support may be requested for $80,000 annually (plus 12 percent for indirect costs).

Term of Contract:

Awards may be approved for up to a two (2) year period. Funding for Year 2 is contingent upon submission and approval of a renewal progress report and the availability of funds.

Additional Eligibility Criteria:

• U.S. residents and applicants from outside the U.S. are welcome to apply.
• International applicants and institutions are required to submit additional information in accordance with USA Patriot Act and the U.S. Department of Treasury Anti-Terrorist Financing Guidelines (see section VI.10.L below).
• Applicants must be independent investigators. Applicants must be independent investigators. An independent investigator is an individual who is out of fellowship training and whose institution allows them to submit applications for research funding as a Principle Investigator.
• Candidates who are clinical fellows should apply to the CFF Clinical Fellowship program for the appropriate year.
• Candidates who are postdoctoral fellows should apply to the CFF Postdoctoral Research Fellowship program.
• Industry-sponsored research projects are not eligible to apply through this program and instead should consider applying to the Therapeutics Development Awards program.

Direct costs for the following are unallowable:
• Tuition

Indirect Costs up to twelve (12) percent may be requested from CFF. Indirect costs may be requested for all
expenses except for the following:
• Equipment (items over US$5,000 in value)
• Computer software
• Software licenses

Applications for continued funding of existing projects, or for long-term support of an investigator, will not be considered.

Pre-Application Information:

Key Dates:

Fall 2021 Cycle
- Published January 25, 2021
- Pre-Registration Deadline* March 5, 2021
- LOI Submission Deadline March 19, 2021 at 5:00 PM (EST)
- LOI Applicant Notified June 2021
- Full Application Deadline August 18, 2021 5:00 PM (EST)
- Committee Review Date October 2021
- Notification to Applicants November 2021
- Earliest Project Start Date January 1, 2022

Applicants are highly encouraged to pre-register your profile, institution, contacts, and Title of your Application by this date. This will confirm that your submission at the Application Deadline, is without any system-related issue. It will also allow staff to assist you on system-related queries before the Application Deadline. This pre-registration is for new applicants to the system and will only need to be completed once.

For all first-time applicants in the new Grants Management System, CFF asks that you pre-register to create a username and password for “” and complete a profile well before the date you plan to submit an application.

More information regarding the research priorities of the CF Foundation can be found here:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online:

For specific questions regarding your proposal and the CF Foundation's research priorities, please contact the Program Officer, Dara Riva (

Grants and Contracts Office:

Please Direct Inquiries to:
Grants and Contracts Office
Cystic Fibrosis Foundation
4550 Montgomery Ave.
Suite 1100 N
Bethesda, MD 20814

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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